Last season she held her own against fashion's young fillies with a skinny jean-clad appearance that was sensational for a busy working mother.
And on day four of the capital's style extravaganza Samantha Cameron reinforced her role as the first lady of fashion.
Joining US Vogue editor Anna Wintour, Laura Bailey and Alexa Chung, the Prime Minister's wife watched the Erdem show in a beautiful dome erected off Bond Street for the occasion.
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Samantha, 41, who is ambassador for the British Fashion Council, was super chic in a blue printed Michael van der Ham dress that was cinched in at the waist with a black belt.
During her fashion week outing, the style maven apparently confessed to rapper Azealia Banks that she loves her risqué song, 212.
Give her edgy taste in music, Erdem's lace dresses and pencil skirts in tangerine, lemon and candyfloss pink were probably too sweet for the political spouse.
But the Canadian-born designer is certain to find more custom coming from his most high profile client, the Duchess of Cambridge – who wore one of his dresses for the couple’s reception in Singapore.
His presentation had stuck to his signature ladylike style, but flecks of neon and snakeskin marked a new, modern direction.
While some of the lightweight dresses may be too sheer for Kate, more demure creations with lace appliqué and floral patterns would be perfect for any summer tours and garden parties next year.
Erdem's sweet treats were matched by Christopher Kane's offerings.
But the collection, in sugary shades of lemon and bubblegum, had a tough edge – they were finished with plastic nuts and bolts.
"I wanted it to be reserved and at the same time, dramatic," Christopher said backstage about the collection which was inspired as much by Frankenstein as it was by confectionery.